Efficient In Vivo Introduction of Point Mutations Using ssODN and a Co-CRISPR Approach

BACKGROUND: The generation of point mutations is a major tool for evaluating the roles of specific nucleotides or amino acids within the regulatory or functional landscape. However, examination of these mutations in vivo requires the generation of animals carrying only the relevant point mutations a...

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Detalles Bibliográficos
Autores principales: Levi, Tgst, Sloutskin, Anna, Kalifa, Rachel, Juven-Gershon, Tamar, Gerlitz, Offer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362497/
https://www.ncbi.nlm.nih.gov/pubmed/32684853
http://dx.doi.org/10.1186/s12575-020-00123-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362497/
https://www.ncbi.nlm.nih.gov/pubmed/32684853
http://dx.doi.org/10.1186/s12575-020-00123-7

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