The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells

BACKGROUND: Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1 interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation and thereafter cancer cell death mediated by T-lymphocyte. Understanding the mechanisms that regulate PD-L1 was of vital...

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Detalles Bibliográficos
Autores principales: Wang, Yu, Sun, Qingguo, Mu, Ning, Sun, Xiaoyang, Wang, Yingying, Fan, Songqing, Su, Ling, Liu, Xiangguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362500/
https://www.ncbi.nlm.nih.gov/pubmed/32665011
http://dx.doi.org/10.1186/s12964-020-00612-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362500/
https://www.ncbi.nlm.nih.gov/pubmed/32665011
http://dx.doi.org/10.1186/s12964-020-00612-y

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