Impairment in dynein-mediated nuclear translocation by BICD2 C-terminal truncation leads to neuronal migration defect and human brain malformation

During brain development, the nucleus of migrating neurons follows the centrosome and translocates into the leading process. Defects in these migratory events, which affect neuronal migration, cause lissencephaly and other neurodevelopmental disorders. However, the mechanism of nuclear translocation...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsai, Meng-Han, Cheng, Haw-Yuan, Nian, Fang-Shin, Liu, Chen, Chao, Nian-Hsin, Chiang, Kuo-Liang, Chen, Shu-Fang, Tsai, Jin-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362644/
https://www.ncbi.nlm.nih.gov/pubmed/32665036
http://dx.doi.org/10.1186/s40478-020-00971-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362644/
https://www.ncbi.nlm.nih.gov/pubmed/32665036
http://dx.doi.org/10.1186/s40478-020-00971-0

Ejemplares similares