Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues

Mutations create genetic variation for other evolutionary forces to operate on and cause numerous genetic diseases. Nevertheless, how de novo mutations arise remains poorly understood. Progress in the area is hindered by the fact that error rates of conventional sequencing technologies (1 in 100 or...

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Detalles Bibliográficos
Autores principales: Arbeithuber, Barbara, Hester, James, Cremona, Marzia A., Stoler, Nicholas, Zaidi, Arslan, Higgins, Bonnie, Anthony, Kate, Chiaromonte, Francesca, Diaz, Francisco J., Makova, Kateryna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363077/
https://www.ncbi.nlm.nih.gov/pubmed/32667908
http://dx.doi.org/10.1371/journal.pbio.3000745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363077/
https://www.ncbi.nlm.nih.gov/pubmed/32667908
http://dx.doi.org/10.1371/journal.pbio.3000745

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