Hypoxia drives the assembly of the multienzyme purinosome complex

The purinosome is a dynamic metabolic complex composed of enzymes responsible for de novo purine biosynthesis, whose formation has been associated with elevated purine demand. However, the physiological conditions that govern purinosome formation in cells remain unknown. Here, we report that purinos...

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Detalles Bibliográficos
Autores principales: Doigneaux, Cyrielle, Pedley, Anthony M., Mistry, Ishna N., Papayova, Monika, Benkovic, Stephen J., Tavassoli, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363121/
https://www.ncbi.nlm.nih.gov/pubmed/32439803
http://dx.doi.org/10.1074/jbc.RA119.012175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363121/
https://www.ncbi.nlm.nih.gov/pubmed/32439803
http://dx.doi.org/10.1074/jbc.RA119.012175

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