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Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33

Pleckstrin homology domain–containing A7 (PLEKHA7) is a cytoplasmic protein at adherens junctions that has been implicated in hypertension, glaucoma, and responses to Staphylococcus aureus α-toxin. Complex formation between PLEKHA7, PDZ domain–containing 11 (PDZD11), tetraspanin 33, and the α-toxin...

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Detalles Bibliográficos
Autores principales: Rouaud, Florian, Tessaro, Francesca, Aimaretti, Laura, Scapozza, Leonardo, Citi, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363125/
https://www.ncbi.nlm.nih.gov/pubmed/32371390
http://dx.doi.org/10.1074/jbc.RA120.012987