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Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer
Colorectal cancer (CRC) is the third leading cause of cancer and second leading cause of cancer death in the United States. Recent evidence has linked a high fat and animal protein diet and microbial metabolism of host bile acids as environmental risk factors for CRC development. We hypothesize that...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363648/ https://www.ncbi.nlm.nih.gov/pubmed/32695922 http://dx.doi.org/10.1016/j.conctc.2020.100611 |
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author | Wolf, Patricia G. Gaskins, H. Rex Ridlon, Jason M. Freels, Sally Hamm, Alyshia Goldberg, Sarah Petrilli, Phyllis Schering, Teresa Vergis, Sevasti Gomez-Perez, Sandra Yazici, Cemal Braunschweig, Carol Mutlu, Ece Tussing-Humphreys, Lisa |
author_facet | Wolf, Patricia G. Gaskins, H. Rex Ridlon, Jason M. Freels, Sally Hamm, Alyshia Goldberg, Sarah Petrilli, Phyllis Schering, Teresa Vergis, Sevasti Gomez-Perez, Sandra Yazici, Cemal Braunschweig, Carol Mutlu, Ece Tussing-Humphreys, Lisa |
author_sort | Wolf, Patricia G. |
collection | PubMed |
description | Colorectal cancer (CRC) is the third leading cause of cancer and second leading cause of cancer death in the United States. Recent evidence has linked a high fat and animal protein diet and microbial metabolism of host bile acids as environmental risk factors for CRC development. We hypothesize that the primary bile salt taurocholic acid (TCA) is a key, diet-controlled metabolite whose use by bacteria yields a carcinogen and tumor-promoter, respectively. The work is motivated by our published data indicating hydrogen sulfide (H(2)S) and secondary bile acid production by colonic bacteria, serve as environmental insults contributing to CRC risk. The central aim of this study is to test whether a diet high in animal protein and saturated fat increases abundance of bacteria that generate H(2)S and pro-inflammatory secondary bile acids in African Americans (AAs) at high risk for CRC. Our prospective, randomized, crossover feeding trial will examine two microbial mechanisms by which an animal-based diet may support the growth of TCA metabolizing bacteria. Each subject will receive two diets in a crossover design― an animal-based diet, rich in taurine and saturated fat, and a plant-based diet, low in taurine and saturated fat. A mediation model will be used to determine the extent to which diet (independent variable) and mucosal markers of CRC risk and DNA damage (dependent variables) are explained by colonic bacteria and their functions (mediator variables). This research will generate novel information targeted to develop effective dietary interventions that may reduce the unequal CRC burden in AAs. |
format | Online Article Text |
id | pubmed-7363648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73636482020-07-20 Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer Wolf, Patricia G. Gaskins, H. Rex Ridlon, Jason M. Freels, Sally Hamm, Alyshia Goldberg, Sarah Petrilli, Phyllis Schering, Teresa Vergis, Sevasti Gomez-Perez, Sandra Yazici, Cemal Braunschweig, Carol Mutlu, Ece Tussing-Humphreys, Lisa Contemp Clin Trials Commun Article Colorectal cancer (CRC) is the third leading cause of cancer and second leading cause of cancer death in the United States. Recent evidence has linked a high fat and animal protein diet and microbial metabolism of host bile acids as environmental risk factors for CRC development. We hypothesize that the primary bile salt taurocholic acid (TCA) is a key, diet-controlled metabolite whose use by bacteria yields a carcinogen and tumor-promoter, respectively. The work is motivated by our published data indicating hydrogen sulfide (H(2)S) and secondary bile acid production by colonic bacteria, serve as environmental insults contributing to CRC risk. The central aim of this study is to test whether a diet high in animal protein and saturated fat increases abundance of bacteria that generate H(2)S and pro-inflammatory secondary bile acids in African Americans (AAs) at high risk for CRC. Our prospective, randomized, crossover feeding trial will examine two microbial mechanisms by which an animal-based diet may support the growth of TCA metabolizing bacteria. Each subject will receive two diets in a crossover design― an animal-based diet, rich in taurine and saturated fat, and a plant-based diet, low in taurine and saturated fat. A mediation model will be used to determine the extent to which diet (independent variable) and mucosal markers of CRC risk and DNA damage (dependent variables) are explained by colonic bacteria and their functions (mediator variables). This research will generate novel information targeted to develop effective dietary interventions that may reduce the unequal CRC burden in AAs. Elsevier 2020-07-08 /pmc/articles/PMC7363648/ /pubmed/32695922 http://dx.doi.org/10.1016/j.conctc.2020.100611 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wolf, Patricia G. Gaskins, H. Rex Ridlon, Jason M. Freels, Sally Hamm, Alyshia Goldberg, Sarah Petrilli, Phyllis Schering, Teresa Vergis, Sevasti Gomez-Perez, Sandra Yazici, Cemal Braunschweig, Carol Mutlu, Ece Tussing-Humphreys, Lisa Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer |
title | Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer |
title_full | Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer |
title_fullStr | Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer |
title_full_unstemmed | Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer |
title_short | Effects of taurocholic acid metabolism by gut bacteria: A controlled feeding trial in adult African American subjects at elevated risk for colorectal cancer |
title_sort | effects of taurocholic acid metabolism by gut bacteria: a controlled feeding trial in adult african american subjects at elevated risk for colorectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363648/ https://www.ncbi.nlm.nih.gov/pubmed/32695922 http://dx.doi.org/10.1016/j.conctc.2020.100611 |
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