“Para-retinal” Vector Administration into the Deep Vitreous Enhances Retinal Transgene Expression

Intravitreal administration for human adeno-associated vector (AAV) delivery is easier and less traumatic to ocular tissues than subretinal injection, but it gives limited retinal transduction. AAV vectors are large (about 4,000 kDa) compared with most intraocular drugs, such as ranibizumab (48 kDa)...

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Detalles Bibliográficos
Autores principales: Zeng, Yong, Boyd, Ryan, Bartoe, Joshua, Wiley, Henry E., Marangoni, Dario, Wei, Lisa L., Sieving, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363691/
https://www.ncbi.nlm.nih.gov/pubmed/32695844
http://dx.doi.org/10.1016/j.omtm.2020.06.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363691/
https://www.ncbi.nlm.nih.gov/pubmed/32695844
http://dx.doi.org/10.1016/j.omtm.2020.06.015

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