Substrate metabolism regulated by Sestrin2–mTORC1 alleviates pressure overload-induced cardiac hypertrophy in aged heart

Sestrin2 (Sesn2) is a stress sensor for the mammalian target of rapamycin complex 1 (mTORC1) pathway. Aging impairs cardiac mTORC1 activation, thereby sensitizing the heart to hypertrophy. C57BL/6 J young wild-type (young WT; 4–6 months), aged WT (24–26 months), and young Sestrin2 knockout mice (Y-S...

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Detalles Bibliográficos
Autores principales: Quan, Nanhu, Li, Xuan, Zhang, Jingwen, Han, Ying, Sun, Weiju, Ren, Di, Tong, Qian, Li, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363709/
https://www.ncbi.nlm.nih.gov/pubmed/32863202
http://dx.doi.org/10.1016/j.redox.2020.101637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363709/
https://www.ncbi.nlm.nih.gov/pubmed/32863202
http://dx.doi.org/10.1016/j.redox.2020.101637

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