Cargando…

Substrate metabolism regulated by Sestrin2–mTORC1 alleviates pressure overload-induced cardiac hypertrophy in aged heart

Sestrin2 (Sesn2) is a stress sensor for the mammalian target of rapamycin complex 1 (mTORC1) pathway. Aging impairs cardiac mTORC1 activation, thereby sensitizing the heart to hypertrophy. C57BL/6 J young wild-type (young WT; 4–6 months), aged WT (24–26 months), and young Sestrin2 knockout mice (Y-S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quan, Nanhu, Li, Xuan, Zhang, Jingwen, Han, Ying, Sun, Weiju, Ren, Di, Tong, Qian, Li, Ji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363709/ https://www.ncbi.nlm.nih.gov/pubmed/32863202 http://dx.doi.org/10.1016/j.redox.2020.101637

Ejemplares similares

Sestrin2 modulates cardiac inflammatory response through maintaining redox homeostasis during ischemia and reperfusion
por: Ren, Di, et al.
Publicado: (2020)

Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload
por: Zhang, Nan, et al.
Publicado: (2021)

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
por: Kim, Jeong Sig, et al.
Publicado: (2015)

The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1
por: Mlitz, Veronika, et al.
Publicado: (2016)

Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
por: Sig Kim, Jeong, et al.
Publicado: (2015)

Nicotinamide Riboside Alleviates Cardiac Dysfunction and Remodeling in Pressure Overload Cardiac Hypertrophy
por: Ma, Sai, et al.
Publicado: (2021)

The Emerging Role of Sestrin2 in Cell Metabolism, and Cardiovascular and Age-Related Diseases
por: Sun, Wanqing, et al.
Publicado: (2020)

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2
por: Ye, Jiangbin, et al.
Publicado: (2015)

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy
por: Gao, Maomao, et al.
Publicado: (2020)

Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling
por: Wang, Xuejin, et al.
Publicado: (2017)

Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling
por: Tao, Rongya, et al.
Publicado: (2015)

Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancer
por: Wei, Jin-Lai, et al.
Publicado: (2017)

Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin
por: Jang, Se-Kyeong, et al.
Publicado: (2021)

Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy
por: Sato, Hiroshi, et al.
Publicado: (1997)

Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation
por: Xue, Ruicong, et al.
Publicado: (2017)

Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway
por: Rani, Shilpa, et al.
Publicado: (2017)

Correction to: Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin
por: Jang, Se-Kyeong, et al.
Publicado: (2021)

Sestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling
por: Yang, Keping, et al.
Publicado: (2017)

Intermedin Suppresses Pressure Overload Cardiac Hypertrophy through Activation of Autophagy
por: Chen, HuaLi, et al.
Publicado: (2013)

Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1
por: Blagojevic, Biljana, et al.
Publicado: (2022)

Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion
por: Ren, Di, et al.
Publicado: (2020)

Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis
por: Gong, Sa, et al.
Publicado: (2023)

Effects of miRNA-455 on cardiac hypertrophy induced by pressure overload
por: WU, CHUNTAO, et al.
Publicado: (2015)

Bezafibrate Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis
por: Xu, Si-Chi, et al.
Publicado: (2017)

IKKi Deficiency Promotes Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis
por: Dai, Jia, et al.
Publicado: (2013)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload
por: Guo, Xinji, et al.
Publicado: (2020)

Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload
Publicado: (2022)

MicroRNA-327 regulates cardiac hypertrophy and fibrosis induced by pressure overload
por: Ji, Yue, et al.
Publicado: (2018)

GPR30 Alleviates Pressure Overload-Induced Myocardial Hypertrophy in Ovariectomized Mice by Regulating Autophagy
por: Zhang, Shuaishuai, et al.
Publicado: (2023)

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy
por: Bentzinger, C Florian, et al.
Publicado: (2013)

Rutaecarpine Ameliorates Pressure Overload Cardiac Hypertrophy by Suppression of Calcineurin and Angiotensin II
por: Li, Shujun, et al.
Publicado: (2021)

Augmented Cardiac Hypertrophy in Response to Pressure Overload in Mice Lacking ELTD1
por: Xiao, Jinfeng, et al.
Publicado: (2012)

Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling
por: Liu, Xin, et al.
Publicado: (2021)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Ganoderma lucidum polysaccharides attenuates pressure-overload-induced pathological cardiac hypertrophy
por: Zhen, Changlin, et al.
Publicado: (2023)

Eosinophils protect pressure overload- and β-adrenoreceptor agonist-induced cardiac hypertrophy
por: Yang, Chongzhe, et al.
Publicado: (2022)

Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload
por: Nordén, Einar Sjaastad, et al.
Publicado: (2021)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_armeucvh64f48j31di43okr2tm