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A STING-based biosensor affords broad cyclic dinucleotide detection within single living eukaryotic cells

Cyclic dinucleotides (CDNs) are second messengers conserved across all three domains of life. Within eukaryotes they mediate protective roles in innate immunity against malignant, viral, and bacterial disease, and exert pathological effects in autoimmune disorders. Despite their ubiquitous role in d...

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Detalles Bibliográficos
Autores principales: Pollock, Alex J., Zaver, Shivam A., Woodward, Joshua J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363834/
https://www.ncbi.nlm.nih.gov/pubmed/32669552
http://dx.doi.org/10.1038/s41467-020-17228-y