The pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis

N-methyl-2-pyrrolidone (NMP) is a versatile water-miscible polar aprotic solvent. It is used as a drug solubilizer and penetration enhancer in human and animal, yet its bioactivity properties remain elusive. Here, we report that NMP is a bioactive anti-inflammatory compound well tolerated in vivo, t...

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Detalles Bibliográficos
Autores principales: Roche-Molina, Marta, Hardwick, Bryn, Sanchez-Ramos, Cristina, Sanz-Rosa, David, Gewert, Dirk, Cruz, Francisco M., Gonzalez-Guerra, Andres, Andres, Vicente, Palma, Joaquin A., Ibanez, Borja, Mckenzie, Grahame, Bernal, Juan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363918/
https://www.ncbi.nlm.nih.gov/pubmed/32669659
http://dx.doi.org/10.1038/s41598-020-68350-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363918/
https://www.ncbi.nlm.nih.gov/pubmed/32669659
http://dx.doi.org/10.1038/s41598-020-68350-2

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