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Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production

BACKGROUND: Co-administration of human ghrelin and growth hormone (GH) reverse immunosuppression in septic aged animals, but the mechanism remains elusive. Here, we hypothesize that ghrelin and GH co-treatment restores the immune response in aged septic rats by inhibiting the production of transform...

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Detalles Bibliográficos
Autores principales: Zhou, Mian, Aziz, Monowar, Ochani, Mahendar, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364485/
https://www.ncbi.nlm.nih.gov/pubmed/32677895
http://dx.doi.org/10.1186/s10020-020-00195-x