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Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance
BACKGROUND: Tumors can evolve and adapt to therapeutic pressure by acquiring genetic and epigenetic alterations that may be transient or stable. A precise understanding of how such events contribute to intratumoral heterogeneity, dynamic subpopulations, and overall tumor fitness will require experim...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364565/ https://www.ncbi.nlm.nih.gov/pubmed/32669109 http://dx.doi.org/10.1186/s13059-020-02085-1 |