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双靶点嵌合抗原受体T细胞治疗CD19抗原表位缺失急性B淋巴细胞白血病一例报告并文献复习
OBJECTIVE: To analyze the influence of CD19 isoforms to the efficacy of CD19/CD3 Bispecific T-cell Engager (BiTE) antibody, and explore the resistance mechanism of BiTE immunotherapy. METHODS: Semi-quantitative RT-PCR (qRT-PCR) was used to detect the expression of CD19 mRNA isoforms before and after...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
Editorial office of Chinese Journal of Hematology
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364923/ https://www.ncbi.nlm.nih.gov/pubmed/32447930 http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.04.004 |