Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

[Image: see text] The putative active metabolite of aeruginascin, a naturally occurring tryptamine of “magic mushrooms,” has been synthesized and structurally characterized. Competitive radioligand binding assays demonstrate that it has a high affinity at human serotonin receptors 5-HT(1A), 5-HT(2A)...

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Autores principales: Chadeayne, Andrew R., Pham, Duyen N. K., Reid, Brian G., Golen, James A., Manke, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365549/
https://www.ncbi.nlm.nih.gov/pubmed/32685863
http://dx.doi.org/10.1021/acsomega.0c02208
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author Chadeayne, Andrew R.
Pham, Duyen N. K.
Reid, Brian G.
Golen, James A.
Manke, David R.
author_facet Chadeayne, Andrew R.
Pham, Duyen N. K.
Reid, Brian G.
Golen, James A.
Manke, David R.
author_sort Chadeayne, Andrew R.
collection PubMed
description [Image: see text] The putative active metabolite of aeruginascin, a naturally occurring tryptamine of “magic mushrooms,” has been synthesized and structurally characterized. Competitive radioligand binding assays demonstrate that it has a high affinity at human serotonin receptors 5-HT(1A), 5-HT(2A), and 5-HT(2B), though it does not bind at the 5-HT(3) receptor, where activity was previously predicted.
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spelling pubmed-73655492020-07-17 Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity Chadeayne, Andrew R. Pham, Duyen N. K. Reid, Brian G. Golen, James A. Manke, David R. ACS Omega [Image: see text] The putative active metabolite of aeruginascin, a naturally occurring tryptamine of “magic mushrooms,” has been synthesized and structurally characterized. Competitive radioligand binding assays demonstrate that it has a high affinity at human serotonin receptors 5-HT(1A), 5-HT(2A), and 5-HT(2B), though it does not bind at the 5-HT(3) receptor, where activity was previously predicted. American Chemical Society 2020-07-02 /pmc/articles/PMC7365549/ /pubmed/32685863 http://dx.doi.org/10.1021/acsomega.0c02208 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Chadeayne, Andrew R.
Pham, Duyen N. K.
Reid, Brian G.
Golen, James A.
Manke, David R.
Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity
title Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity
title_full Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity
title_fullStr Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity
title_full_unstemmed Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity
title_short Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity
title_sort active metabolite of aeruginascin (4-hydroxy-n,n,n-trimethyltryptamine): synthesis, structure, and serotonergic binding affinity
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365549/
https://www.ncbi.nlm.nih.gov/pubmed/32685863
http://dx.doi.org/10.1021/acsomega.0c02208
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