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Exploring the catalytic cascade of cembranoid biosynthesis by combination of genetic engineering and molecular simulations

While chemical steps involved in bioactive cembranoid biosynthesis have been examined, the corresponding enzymatic mechanisms leading to their formation remain elusive. In the tobacco plant, Nicotiana tabacum, a putative cembratriene-ol synthase (CBTS) initiates the catalytic cascade that lead to th...

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Detalles Bibliográficos
Autores principales: Schrepfer, Patrick, Ugur, Ilke, Klumpe, Sven, Loll, Bernhard, Kaila, Ville R.I., Brück, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365961/
https://www.ncbi.nlm.nih.gov/pubmed/32695274
http://dx.doi.org/10.1016/j.csbj.2020.06.030