Rapamycin inhibits AR signaling pathway in prostate cancer by interacting with the FK1 domain of FKBP51

Reactivation of the androgen receptor signaling pathway in the emasculated environment is the main reason for the occurrence of castration-resistant prostate cancer (CRPC). The immunophilin FKBP51, as a co-chaperone protein, together with Hsp90 help the correct folding of AR. Rapamycin is a known sm...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Wu, Dan, He, Yongxing, Li, Lanlan, Liu, Shanhui, Lu, Jianzhong, Gui, Huiming, Wang, Yuhan, Tao, Yan, Wang, Hanzhang, Kaushik, Dharam, Rodriguez, Ronald, Wang, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365970/
https://www.ncbi.nlm.nih.gov/pubmed/32695889
http://dx.doi.org/10.1016/j.bbrep.2020.100778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365970/
https://www.ncbi.nlm.nih.gov/pubmed/32695889
http://dx.doi.org/10.1016/j.bbrep.2020.100778

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