Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand

[Image: see text] A highly Me(2)Zn-mediated catalytic enantioselective Reformatsky reaction of aldehydes and ketones with ethyl iodoacetate using a readily available prolinol ligand is reported. This reaction provides an efficient method for the construction of β-hydroxy esters in up to 98% yield an...

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Autores principales: Ouyang, Lu, Xia, YanPing, Wei, YiFei, Liao, Jianhua, Luo, Renshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366354/
https://www.ncbi.nlm.nih.gov/pubmed/32685867
http://dx.doi.org/10.1021/acsomega.0c02400
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author Ouyang, Lu
Xia, YanPing
Wei, YiFei
Liao, Jianhua
Luo, Renshi
author_facet Ouyang, Lu
Xia, YanPing
Wei, YiFei
Liao, Jianhua
Luo, Renshi
author_sort Ouyang, Lu
collection PubMed
description [Image: see text] A highly Me(2)Zn-mediated catalytic enantioselective Reformatsky reaction of aldehydes and ketones with ethyl iodoacetate using a readily available prolinol ligand is reported. This reaction provides an efficient method for the construction of β-hydroxy esters in up to 98% yield and 95% enantiomeric excess (ee) value. A wide range of functional groups are tolerated and the practicality of this protocol is demonstrated by performing the reaction on a gram scale.
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spelling pubmed-73663542020-07-17 Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand Ouyang, Lu Xia, YanPing Wei, YiFei Liao, Jianhua Luo, Renshi ACS Omega [Image: see text] A highly Me(2)Zn-mediated catalytic enantioselective Reformatsky reaction of aldehydes and ketones with ethyl iodoacetate using a readily available prolinol ligand is reported. This reaction provides an efficient method for the construction of β-hydroxy esters in up to 98% yield and 95% enantiomeric excess (ee) value. A wide range of functional groups are tolerated and the practicality of this protocol is demonstrated by performing the reaction on a gram scale. American Chemical Society 2020-06-26 /pmc/articles/PMC7366354/ /pubmed/32685867 http://dx.doi.org/10.1021/acsomega.0c02400 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ouyang, Lu
Xia, YanPing
Wei, YiFei
Liao, Jianhua
Luo, Renshi
Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand
title Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand
title_full Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand
title_fullStr Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand
title_full_unstemmed Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand
title_short Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand
title_sort highly catalytic enantioselective reformatsky reaction with aldehydes and ketones using an available prolinol ligand
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366354/
https://www.ncbi.nlm.nih.gov/pubmed/32685867
http://dx.doi.org/10.1021/acsomega.0c02400
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