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Synthesis of Ir(III) Hydrido Complexes by Oxidative Addition of Halogenated Theophylline and Adenine Derivatives
[Image: see text] The Ir(III) hydrido complexes [1] and [2] have been synthesized by the regioselective oxidative addition of the N7–H bond of 8-halogenotheophyllines to [IrCl(coe)(2)](2) in the presence of PPh(3). The use of dppf in this reaction yielded the bimetallic Ir(III)/Fe(II) hydrido comple...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366355/ https://www.ncbi.nlm.nih.gov/pubmed/32685865 http://dx.doi.org/10.1021/acsomega.0c02290 |
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author | Blumenberg, Jonas Kampert, Florian Hepp, Alexander Hahn, F. Ekkehardt |
author_facet | Blumenberg, Jonas Kampert, Florian Hepp, Alexander Hahn, F. Ekkehardt |
author_sort | Blumenberg, Jonas |
collection | PubMed |
description | [Image: see text] The Ir(III) hydrido complexes [1] and [2] have been synthesized by the regioselective oxidative addition of the N7–H bond of 8-halogenotheophyllines to [IrCl(coe)(2)](2) in the presence of PPh(3). The use of dppf in this reaction yielded the bimetallic Ir(III)/Fe(II) hydrido complexes [3] and [4]. X-ray diffraction studies confirmed that complexes [1]–[4] feature a theophyllinato ligand coordinated to the metal center in the rarely observed, chelating fashion via the N7 and O1 atoms. In addition, 8-bromoadenine reacts with [IrCl(coe)(2)](2) in the presence of PPh(3) to form the Ir(III) hydrido complex [5] which features one anionic 8-bromoadeninato and one neutral 8-bromoadenine ligand linked by an intramolecular hydrogen bond. Complex [5] was characterized by high-resolution mass spectrometry and an X-ray diffraction analysis but could not be analyzed by nuclear magnetic resonance spectroscopy because of its low solubility. |
format | Online Article Text |
id | pubmed-7366355 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-73663552020-07-17 Synthesis of Ir(III) Hydrido Complexes by Oxidative Addition of Halogenated Theophylline and Adenine Derivatives Blumenberg, Jonas Kampert, Florian Hepp, Alexander Hahn, F. Ekkehardt ACS Omega [Image: see text] The Ir(III) hydrido complexes [1] and [2] have been synthesized by the regioselective oxidative addition of the N7–H bond of 8-halogenotheophyllines to [IrCl(coe)(2)](2) in the presence of PPh(3). The use of dppf in this reaction yielded the bimetallic Ir(III)/Fe(II) hydrido complexes [3] and [4]. X-ray diffraction studies confirmed that complexes [1]–[4] feature a theophyllinato ligand coordinated to the metal center in the rarely observed, chelating fashion via the N7 and O1 atoms. In addition, 8-bromoadenine reacts with [IrCl(coe)(2)](2) in the presence of PPh(3) to form the Ir(III) hydrido complex [5] which features one anionic 8-bromoadeninato and one neutral 8-bromoadenine ligand linked by an intramolecular hydrogen bond. Complex [5] was characterized by high-resolution mass spectrometry and an X-ray diffraction analysis but could not be analyzed by nuclear magnetic resonance spectroscopy because of its low solubility. American Chemical Society 2020-06-29 /pmc/articles/PMC7366355/ /pubmed/32685865 http://dx.doi.org/10.1021/acsomega.0c02290 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Blumenberg, Jonas Kampert, Florian Hepp, Alexander Hahn, F. Ekkehardt Synthesis of Ir(III) Hydrido Complexes by Oxidative Addition of Halogenated Theophylline and Adenine Derivatives |
title | Synthesis of Ir(III) Hydrido Complexes by
Oxidative Addition of Halogenated Theophylline and Adenine Derivatives |
title_full | Synthesis of Ir(III) Hydrido Complexes by
Oxidative Addition of Halogenated Theophylline and Adenine Derivatives |
title_fullStr | Synthesis of Ir(III) Hydrido Complexes by
Oxidative Addition of Halogenated Theophylline and Adenine Derivatives |
title_full_unstemmed | Synthesis of Ir(III) Hydrido Complexes by
Oxidative Addition of Halogenated Theophylline and Adenine Derivatives |
title_short | Synthesis of Ir(III) Hydrido Complexes by
Oxidative Addition of Halogenated Theophylline and Adenine Derivatives |
title_sort | synthesis of ir(iii) hydrido complexes by
oxidative addition of halogenated theophylline and adenine derivatives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366355/ https://www.ncbi.nlm.nih.gov/pubmed/32685865 http://dx.doi.org/10.1021/acsomega.0c02290 |
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