Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding

Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced pluripotent stem cell-based model, we ai...

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Detalles Bibliográficos
Autores principales: Garone, Maria Giovanna, Alfano, Vincenzo, Salvatori, Beatrice, Braccia, Clarissa, Peruzzi, Giovanna, Colantoni, Alessio, Bozzoni, Irene, Armirotti, Andrea, Rosa, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366621/
https://www.ncbi.nlm.nih.gov/pubmed/32678235
http://dx.doi.org/10.1038/s41598-020-68794-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366621/
https://www.ncbi.nlm.nih.gov/pubmed/32678235
http://dx.doi.org/10.1038/s41598-020-68794-6

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