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Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters

Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic treatment by entering a dormant state. The emergence of persisters from dormancy after antibiotic withdrawal leads to recurrent infection. Indole is an aromatic molecule with diverse signalling roles, including...

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Detalles Bibliográficos
Autores principales: Zarkan, Ashraf, Matuszewska, Marta, Trigg, Stephen B., Zhang, Meng, Belgami, Daaniyah, Croft, Cameron, Liu, Junyan, El-Ouisi, Sawssen, Greenhalgh, Jack, Duboff, James S., Rahman, Taufiq, Summers, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366635/
https://www.ncbi.nlm.nih.gov/pubmed/32678197
http://dx.doi.org/10.1038/s41598-020-68693-w