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Inhibition of indole production increases the activity of quinolone antibiotics against E. coli persisters
Persisters are a sub-population of genetically sensitive bacteria that survive antibiotic treatment by entering a dormant state. The emergence of persisters from dormancy after antibiotic withdrawal leads to recurrent infection. Indole is an aromatic molecule with diverse signalling roles, including...
Autores principales: | Zarkan, Ashraf, Matuszewska, Marta, Trigg, Stephen B., Zhang, Meng, Belgami, Daaniyah, Croft, Cameron, Liu, Junyan, El-Ouisi, Sawssen, Greenhalgh, Jack, Duboff, James S., Rahman, Taufiq, Summers, David K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366635/ https://www.ncbi.nlm.nih.gov/pubmed/32678197 http://dx.doi.org/10.1038/s41598-020-68693-w |
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