A strong preference for the TA/TA dinucleotide step discovered for an acridine-based, potent antitumor dsDNA intercalator, C-1305: NMR-driven structural and sequence-specificity studies

Triazoloacridinone C-1305, a potent antitumor agent recommended for Phase I clinical trials, exhibits high activity towards a wide range of experimental colon carcinomas, in many cases associated with complete tumor regression. C-1305 is a well-established dsDNA intercalator, yet no information on i...

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Detalles Bibliográficos
Autores principales: Laskowski, Tomasz, Andrałojć, Witold, Grynda, Jakub, Gwarda, Paulina, Mazerski, Jan, Gdaniec, Zofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366671/
https://www.ncbi.nlm.nih.gov/pubmed/32678133
http://dx.doi.org/10.1038/s41598-020-68609-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366671/
https://www.ncbi.nlm.nih.gov/pubmed/32678133
http://dx.doi.org/10.1038/s41598-020-68609-8

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