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Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. Trajectory modeling together with lineage tracing revealed th...

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Detalles Bibliográficos
Autores principales: Strunz, Maximilian, Simon, Lukas M., Ansari, Meshal, Kathiriya, Jaymin J., Angelidis, Ilias, Mayr, Christoph H., Tsidiridis, George, Lange, Marius, Mattner, Laura F., Yee, Min, Ogar, Paulina, Sengupta, Arunima, Kukhtevich, Igor, Schneider, Robert, Zhao, Zhongming, Voss, Carola, Stoeger, Tobias, Neumann, Jens H. L., Hilgendorff, Anne, Behr, Jürgen, O’Reilly, Michael, Lehmann, Mareike, Burgstaller, Gerald, Königshoff, Melanie, Chapman, Harold A., Theis, Fabian J., Schiller, Herbert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366678/
https://www.ncbi.nlm.nih.gov/pubmed/32678092
http://dx.doi.org/10.1038/s41467-020-17358-3