Genetic variation in the farnesoid X-receptor predicts Crohn’s disease severity in female patients

The farnesoid X receptor (FXR) is implicated in Crohn's disease (CD) pathogenesis. It is unclear how genetic variation in FXR impacts CD severity versus genetic variation in nuclear receptors such as pregnane X receptor (PXR) and the multi-drug resistance protein 1 (MDR1, ABCB1). To evaluate FX...

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Detalles Bibliográficos
Autores principales: Wilson, Aze, Wang, Qian, Almousa, Ahmed A., Jansen, Laura E., Choi, Yun-hee, Schwarz, Ute I., Kim, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366697/
https://www.ncbi.nlm.nih.gov/pubmed/32678214
http://dx.doi.org/10.1038/s41598-020-68686-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366697/
https://www.ncbi.nlm.nih.gov/pubmed/32678214
http://dx.doi.org/10.1038/s41598-020-68686-9

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