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Genetic variation in the farnesoid X-receptor predicts Crohn’s disease severity in female patients

The farnesoid X receptor (FXR) is implicated in Crohn's disease (CD) pathogenesis. It is unclear how genetic variation in FXR impacts CD severity versus genetic variation in nuclear receptors such as pregnane X receptor (PXR) and the multi-drug resistance protein 1 (MDR1, ABCB1). To evaluate FX...

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Detalles Bibliográficos
Autores principales:	Wilson, Aze, Wang, Qian, Almousa, Ahmed A., Jansen, Laura E., Choi, Yun-hee, Schwarz, Ute I., Kim, Richard B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366697/ https://www.ncbi.nlm.nih.gov/pubmed/32678214 http://dx.doi.org/10.1038/s41598-020-68686-9

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