Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways

The mammalian target of rapamycin (mTOR) functions as two complexes (mTORC1 and mTORC2), regulating cell growth and metabolism. Aberrant mTOR signaling occurs frequently in cancers, so mTOR has become an attractive target for cancer therapy. Iron chelators have emerged as promising anticancer agents...

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Detalles Bibliográficos
Autores principales: Shang, Chaowei, Zhou, Hongyu, Liu, Wang, Shen, Tao, Luo, Yan, Huang, Shile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366895/
https://www.ncbi.nlm.nih.gov/pubmed/32541839
http://dx.doi.org/10.1038/s41388-020-1366-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366895/
https://www.ncbi.nlm.nih.gov/pubmed/32541839
http://dx.doi.org/10.1038/s41388-020-1366-5

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