Polyethylene glycol (5,000) succinate conjugate of lopinavir and its associated toxicity using Danio rerio as a model organism

Lopinavir (LPV), a well-known drug administered in human immunodeficiency virus (HIV) infection, has shown limitation for pediatric treatment owing to poor aqueous solubility that gives rise to limited oral bioavailability and short plasma half-life (5–6 h). Polymers such as polyethylene glycol (PEG...

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Detalles Bibliográficos
Autores principales: Aremu, Oluwole Samuel, Katata-Seru, Lebogang, Mkhize, Zimbili, Botha, Tarryn Lee, Wepener, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366934/
https://www.ncbi.nlm.nih.gov/pubmed/32678162
http://dx.doi.org/10.1038/s41598-020-68666-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366934/
https://www.ncbi.nlm.nih.gov/pubmed/32678162
http://dx.doi.org/10.1038/s41598-020-68666-z

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