Metabolic cofactors NADH and FAD act as non-canonical initiating substrates for a primase and affect replication primer processing in vitro

To initiate replication on a double-stranded DNA de novo, all organisms require primase, an RNA polymerase making short RNA primers which are then extended by DNA polymerases. Here, we show that primase can use metabolic cofactors as initiating substrates, instead of its canonical substrate ATP. Dna...

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Detalles Bibliográficos
Autores principales: Julius, Christina, Salgado, Paula S, Yuzenkova, Yulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367122/
https://www.ncbi.nlm.nih.gov/pubmed/32463447
http://dx.doi.org/10.1093/nar/gkaa447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367122/
https://www.ncbi.nlm.nih.gov/pubmed/32463447
http://dx.doi.org/10.1093/nar/gkaa447

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