AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop

Base excision repair (BER) maintains genomic stability through the repair of DNA damage. Within BER, AP-endonuclease 1 (APE1) is a multifunctional enzyme that processes DNA intermediates through its backbone cleavage activity. To accomplish these repair activities, APE1 must recognize and accommodat...

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Detalles Bibliográficos
Autores principales: Hoitsma, Nicole M, Whitaker, Amy M, Beckwitt, Emily C, Jang, Sunbok, Agarwal, Pratul K, Van Houten, Bennett, Freudenthal, Bret D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367167/
https://www.ncbi.nlm.nih.gov/pubmed/32542366
http://dx.doi.org/10.1093/nar/gkaa496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367167/
https://www.ncbi.nlm.nih.gov/pubmed/32542366
http://dx.doi.org/10.1093/nar/gkaa496

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