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CLICK-17, a DNA enzyme that harnesses ultra-low concentrations of either Cu(+) or Cu(2+) to catalyze the azide-alkyne ‘click’ reaction in water
To enable the optimal, biocompatible and non-destructive application of the highly useful copper (Cu(+))-mediated alkyne-azide ‘click’ cycloaddition in water, we have isolated and characterized a 79-nucleotide DNA enzyme or DNAzyme, ‘CLICK-17’, that harnesses as low as sub-micromolar Cu(+); or, surp...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367168/ https://www.ncbi.nlm.nih.gov/pubmed/32520335 http://dx.doi.org/10.1093/nar/gkaa502 |