Crystal structure and ligand-induced folding of the SAM/SAH riboswitch

While most SAM riboswitches strongly discriminate between SAM and SAH, the SAM/SAH riboswitch responds to both ligands with similar apparent affinities. We have determined crystal structures of the SAM/SAH riboswitch bound to SAH, SAM and other variant ligands at high resolution. The riboswitch form...

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Detalles Bibliográficos
Autores principales: Huang, Lin, Liao, Ting-Wei, Wang, Jia, Ha, Taekjip, Lilley, David M J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367207/
https://www.ncbi.nlm.nih.gov/pubmed/32520325
http://dx.doi.org/10.1093/nar/gkaa493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367207/
https://www.ncbi.nlm.nih.gov/pubmed/32520325
http://dx.doi.org/10.1093/nar/gkaa493

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