TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ

The modulation of GLI2, an oncogenic transcription factor commonly upregulated in cancer, is in many cases not due to genetic defects, suggesting dysregulation through alternative mechanisms. The identity of these molecular events remains for the most part unknown. Here, we identified TFII-I as a no...

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Detalles Bibliográficos
Autores principales: McCleary-Wheeler, Angela L, Paradise, Brooke D, Almada, Luciana L, Carlson, Annika J, Marks, David L, Vrabel, Anne, Vera, Renzo E, Sigafoos, Ashley N, Olson, Rachel L, Fernandez-Zapico, Martin E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367210/
https://www.ncbi.nlm.nih.gov/pubmed/32544250
http://dx.doi.org/10.1093/nar/gkaa476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367210/
https://www.ncbi.nlm.nih.gov/pubmed/32544250
http://dx.doi.org/10.1093/nar/gkaa476

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