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“Oil-soluble” reversed lipid nanoparticles for oral insulin delivery

BACKGROUND: In this study, we aimed to design a novel oral insulin delivery system, named “oil-soluble” reversed lipid nanoparticles (ORLN), in which a hydrophilic insulin molecule is encapsulated by a phospholipid (PC) shell and dissolved in oil to prevent the enzymatic degradation of insulin. ORLN...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Shen, Liao, Zhang, Yadan, Li, Haiyan, Wang, Yongan, Quan, Dongqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367322/
https://www.ncbi.nlm.nih.gov/pubmed/32680576
http://dx.doi.org/10.1186/s12951-020-00657-8