Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae

The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. To gain insight into these mechanisms, we determined the effects of VPA on energy metabolism in yeast. VPA t...

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Detalles Bibliográficos
Autores principales: Salsaa, Michael, Pereira, Bianca, Liu, Jenney, Yu, Wenxi, Jadhav, Shyamalagauri, Hüttemann, Maik, Greenberg, Miriam L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367371/
https://www.ncbi.nlm.nih.gov/pubmed/32678210
http://dx.doi.org/10.1038/s41598-020-68725-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367371/
https://www.ncbi.nlm.nih.gov/pubmed/32678210
http://dx.doi.org/10.1038/s41598-020-68725-5

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