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Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae
The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. To gain insight into these mechanisms, we determined the effects of VPA on energy metabolism in yeast. VPA t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367371/ https://www.ncbi.nlm.nih.gov/pubmed/32678210 http://dx.doi.org/10.1038/s41598-020-68725-5 |