Cargando…

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence

Azole resistant fungal infections remain a health problem for the immune compromised. Current therapies are limited due to rises in new resistance mechanisms. Therefore, it is important to identify new drug targets for drug discovery and novel therapeutics. Arv1 (are1 are2 required for viability 1)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villasmil, Michelle L., Barbosa, Antonio Daniel, Cunningham, Jessie Lee, Siniossoglou, Symeon, Nickels, Joseph T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367482/ https://www.ncbi.nlm.nih.gov/pubmed/32678853 http://dx.doi.org/10.1371/journal.pone.0235746

Ejemplares similares

Computational insights into fluconazole resistance by the suspected mutations in lanosterol 14α-demethylase (Erg11p) of Candida albicans
por: Prakash, Sagunthala Murugesan Udaya, et al.
Publicado: (2020)

Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14 α-demethylase (ERG11) gene of Moniliophthora perniciosa
por: de Oliveira Ceita, Geruza, et al.
Publicado: (2014)

Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14α-Demethylase as a Surrogate
por: Graham, Danyon O., et al.
Publicado: (2021)

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against Candida Yeast by Inhibition of Lanosterol 14-Alpha Demethylase
por: Marin, Victor, et al.
Publicado: (2020)

Identification of 1, 2, 4-Triazine and Its Derivatives Against Lanosterol 14-Demethylase (CYP51) Property of Candida albicans: Influence on the Development of New Antifungal Therapeutic Strategies
por: Verma, Abhishek Kumar, et al.
Publicado: (2022)

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals
por: Tyndall, Joel D. A., et al.
Publicado: (2016)

Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase
por: Sewell, Thomas R., et al.
Publicado: (2017)

K143R Amino Acid Substitution in 14-α-Demethylase (Erg11p) Changes Plasma Membrane and Cell Wall Structure of Candida albicans
por: Derkacz, Daria, et al.
Publicado: (2022)

ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection
por: Zhou, Yujie, et al.
Publicado: (2018)

Flavones, Flavonols, and Glycosylated Derivatives—Impact on Candida albicans Growth and Virulence, Expression of CDR1 and ERG11, Cytotoxicity
por: Ivanov, Marija, et al.
Publicado: (2020)

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase
por: Sagatova, Alia A., et al.
Publicado: (2016)

Detection of ERG11 point mutations in Iranian fluconazole-resistant Candida albicans isolates
por: Sardari, Ali, et al.
Publicado: (2019)

The Role of ERG11 Point Mutations in the Resistance of Candida albicans to Fluconazole in the Presence of Lactate
por: Urbanek, Aneta K., et al.
Publicado: (2022)

Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors
por: Stana, Anca, et al.
Publicado: (2017)

Intrinsic short-tailed azole resistance in mucormycetes is due to an evolutionary conserved aminoacid substitution of the lanosterol 14α-demethylase
por: Caramalho, Rita, et al.
Publicado: (2017)

Effect of Carum carvi essential oil on ERG6 gene expression and virulence factors in Candida albicans
por: Nasiri, Samira, et al.
Publicado: (2020)

P432 Detection of erg11 gene mutation in fluconazole resistant Candida albicans isolates
por: M.S., Sheena, et al.
Publicado: (2022)

Data on molecular docking of tautomers and enantiomers of ATTAF-1 and ATTAF-2 selectivty to the human/fungal lanosterol-14α-demethylase
por: Irannejad, Hamid, et al.
Publicado: (2020)

The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6
por: Scott, Nicola A., et al.
Publicado: (2020)

Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review
por: Siswina, Tessa, et al.
Publicado: (2023)

Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Candida albicans
por: Alizadeh, F, et al.
Publicado: (2017)

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans
por: Odiba, Arome Solomon, et al.
Publicado: (2022)

First detection of mutated ERG11 gene in vulvovaginal Candida albicans isolates at Ouagadougou/Burkina Faso
por: Dovo, Essi Etonam, et al.
Publicado: (2022)

Pathogenesis and virulence of Candida albicans
por: Lopes, José Pedro, et al.
Publicado: (2021)

Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3′-Disulfate
por: Kaluzhskiy, Leonid, et al.
Publicado: (2021)

Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase
por: Carvajal, Silvia Katherine, et al.
Publicado: (2023)

Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence
por: McCourt, Paula, et al.
Publicado: (2016)

Pathogenesis and Virulence of Candida albicans and Candida glabrata
por: Henriques, Mariana, et al.
Publicado: (2020)

Phosphate in Virulence of Candida albicans and Candida glabrata
por: Köhler, Julia R., et al.
Publicado: (2020)

Triazole Derivatives Target 14α–Demethylase (LDM) Enzyme in Candida albicans Causing Ergosterol Biosynthesis Inhibition
por: Rather, Irfan A., et al.
Publicado: (2022)

Principles of a New Protocol for Prediction of Azole Resistance in Candida albicans Infections on the Basis of ERG11 Polymorphisms
por: Caban, Monika, et al.
Publicado: (2016)

Extensive ERG11 mutations associated with fluconazole-resistant Candida albicans isolated from HIV-infected patients
por: Paul, Sony, et al.
Publicado: (2019)

Regulation of ERG3, ERG6, and ERG11 Genes in Antifungal-Resistant isolates of Candida parapsilosis
por: Lotfali, Ensieh, et al.
Publicado: (2017)

Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance
por: Alvarez-Rueda, Nidia, et al.
Publicado: (2011)

High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11
por: Du Bois, Antonia C., et al.
Publicado: (2022)

Upregulation of the ERG11 gene in Candida krusei by azoles
por: Tavakoli, M., et al.
Publicado: (2010)

Functionalized Derivatives of Benzo-Crown Ethers. Part 4. Antifungal Macrocyclic Supramolecular Complexes of Transition Metal Ions Acting as Lanosterol-14-α-Demethylase Ihibitors
por: Barboiu, Mihai, et al.
Publicado: (1999)

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions
por: Warrilow, Andrew G., et al.
Publicado: (2019)

Expression of ERG11, ERG3, MDR1 and CDR1 genes in Candida tropicalis
por: Rojas, Ana Elisa, et al.
Publicado: (2023)

Tetracycline Effects on Candida Albicans Virulence Factors
por: McCool, Logan, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_9uocsa7mn0vdfh0lfkfcfs5bd4