Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

Following agonist activation, G protein-coupled receptors (GPCRs) recruit β-arrestin, which desensitizes heterotrimeric G protein signaling and promotes receptor endocytosis(1). Additionally, β-arrestin directly regulates many cell signaling pathways that can induce cellular responses distinct from...

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Detalles Bibliográficos
Autores principales: Staus, Dean P., Hu, Hongli, Robertson, Michael J., Kleinhenz, Alissa L. W., Wingler, Laura M., Capel, William D., Latorraca, Naomi R., Lefkowitz, Robert J., Skiniotis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367492/
https://www.ncbi.nlm.nih.gov/pubmed/31945772
http://dx.doi.org/10.1038/s41586-020-1954-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367492/
https://www.ncbi.nlm.nih.gov/pubmed/31945772
http://dx.doi.org/10.1038/s41586-020-1954-0

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