Cargando…

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

Following agonist activation, G protein-coupled receptors (GPCRs) recruit β-arrestin, which desensitizes heterotrimeric G protein signaling and promotes receptor endocytosis(1). Additionally, β-arrestin directly regulates many cell signaling pathways that can induce cellular responses distinct from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Staus, Dean P., Hu, Hongli, Robertson, Michael J., Kleinhenz, Alissa L. W., Wingler, Laura M., Capel, William D., Latorraca, Naomi R., Lefkowitz, Robert J., Skiniotis, Georgios
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367492/ https://www.ncbi.nlm.nih.gov/pubmed/31945772 http://dx.doi.org/10.1038/s41586-020-1954-0

Ejemplares similares

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19
por: Manglik, Aashish, et al.
Publicado: (2020)

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes
por: Pakharukova, Natalia, et al.
Publicado: (2021)

Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor
por: Pani, Biswaranjan, et al.
Publicado: (2021)

Catalytic activation of β-arrestin by GPCRs
por: Eichel, Kelsie, et al.
Publicado: (2018)

Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1
por: Huang, Weijiao, et al.
Publicado: (2020)

Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide
por: Shukla, Arun K., et al.
Publicado: (2013)

Lipid Internal Dynamics Probed in Nanodiscs
por: Martinez, Denis, et al.
Publicado: (2017)

Gα(i) is required for carvedilol-induced β(1) adrenergic receptor β-arrestin biased signaling
por: Wang, Jialu, et al.
Publicado: (2017)

Muscarinic Acetylcholine Receptor M3 Modulates Odorant Receptor Activity via Inhibition of β-Arrestin-2 Recruitment
por: Jiang, Yue, et al.
Publicado: (2015)

ERK5 Activation by Gq-Coupled Muscarinic Receptors Is Independent of Receptor Internalization and β-Arrestin Recruitment
por: Sánchez-Fernández, Guzmán, et al.
Publicado: (2013)

Biomimetic Silica Encapsulation of Lipid Nanodiscs and β-Sheet-Stabilized Diacylglycerol Kinase
por: Bialas, Friedrich, et al.
Publicado: (2021)

Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs
por: Iadanza, Matthew G., et al.
Publicado: (2020)

β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
por: Ahn, Seungkirl, et al.
Publicado: (2009)

Structure of SARS-CoV-2 M protein in lipid nanodiscs
por: Dolan, Kimberly A., et al.
Publicado: (2023)

Structure of SARS-CoV-2 M protein in lipid nanodiscs
por: Dolan, Kimberly A, et al.
Publicado: (2022)

Interpretation of solution scattering data from lipid nanodiscs
por: Graziano, Vito, et al.
Publicado: (2018)

Circularized fluorescent nanodiscs for probing protein–lipid interactions
por: Ren, Qian, et al.
Publicado: (2022)

The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus
por: Zang, Yunxiang, et al.
Publicado: (2021)

Nanodisc-T(m): Rapid functional assessment of nanodisc reconstituted membrane proteins by CPM assay
por: Ashok, Yashwanth, et al.
Publicado: (2016)

Cryo-EM structure of mouse TRPML2 in lipid nanodiscs
por: Song, Xiaojing, et al.
Publicado: (2021)

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin
por: Kahsai, Alem W., et al.
Publicado: (2023)

Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
por: Arkhipova, Valentina, et al.
Publicado: (2020)

Fast Collisional Lipid Transfer Among Polymer-Bounded Nanodiscs
por: Cuevas Arenas, Rodrigo, et al.
Publicado: (2017)

Confinement in Nanodiscs Anisotropically Modifies Lipid Bilayer Elastic Properties
por: Schachter, Itay, et al.
Publicado: (2020)

Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs
por: Tucker, Kyle, et al.
Publicado: (2022)

A comparative study of interfacial environments in lipid nanodiscs and vesicles
por: You, Xiao, et al.
Publicado: (2022)

Molecular Dynamics Simulation of Apolipoprotein E3 Lipid Nanodiscs
por: Allen, Patrick, et al.
Publicado: (2023)

Disentangling bias between G(q), GRK2, and arrestin3 recruitment to the M(3) muscarinic acetylcholine receptor
por: Flöser, Anja, et al.
Publicado: (2021)

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
por: Kim, Jihee, et al.
Publicado: (2018)

Polymer-Encased Nanodiscs and Polymer Nanodiscs: New Platforms for Membrane Protein Research and Applications
por: Chen, Angela, et al.
Publicado: (2020)

Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking
por: Wang, Dongxue, et al.
Publicado: (2023)

β-Arrestin Regulation of Myosin Light Chain Phosphorylation Promotes AT1aR-mediated Cell Contraction and Migration
por: Simard, Elie, et al.
Publicado: (2013)

Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex
por: Nguyen, Anthony H., et al.
Publicado: (2021)

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M(1 )vs M(2 )muscarinic acetylcholine receptors
por: Mosser, Valerie A, et al.
Publicado: (2008)

Anisotropic metal growth on phospholipid nanodiscs via lipid bilayer expansion
por: Oertel, Jana, et al.
Publicado: (2016)

Reconstitution and functional characterization of ion channels from nanodiscs in lipid bilayers
por: Winterstein, Laura-Marie, et al.
Publicado: (2018)

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
por: Gao, Yuan, et al.
Publicado: (2016)

Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs
por: Kumar, Arvind, et al.
Publicado: (2020)

Author Correction: Circularized fluorescent nanodiscs for probing protein–lipid interactions
por: Ren, Qian, et al.
Publicado: (2022)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q5lfipjc72orduhromu6lo1bkb