Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice

Genetic alterations of tumor suppressor genes (TSGs) are frequently observed to have cumulative or cooperative tumorigenic effects. We examined whether the TSGs Rb1, Trp53, Pten and Men1 have cooperative effects in suppressing neuroendocrine tumors (NETs) in mice. We generated pairwise homozygous de...

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Detalles Bibliográficos
Autores principales: Xu, Eugenia Y., Vosburgh, Evan, Wong, Chung, Tang, Laura H., Notterman, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367653/
https://www.ncbi.nlm.nih.gov/pubmed/32733644
http://dx.doi.org/10.18632/oncotarget.27660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367653/
https://www.ncbi.nlm.nih.gov/pubmed/32733644
http://dx.doi.org/10.18632/oncotarget.27660

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