A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes

Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death worldwide. High Akt activation and aberrant β-catenin expression contribute to HCC cell proliferation, stem cell generation, and metastasis. Several signaling pathway-specific inhibitors are in clinical trials and disp...

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Detalles Bibliográficos
Autores principales: Patra, Tapas, Meyer, Keith, Ray, Ratna B., Ray, Ranjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367822/
https://www.ncbi.nlm.nih.gov/pubmed/32681102
http://dx.doi.org/10.1038/s41419-020-02741-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367822/
https://www.ncbi.nlm.nih.gov/pubmed/32681102
http://dx.doi.org/10.1038/s41419-020-02741-1

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