A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer

Genetic variation at the 8q24 locus is linked with the greater susceptibility to prostate cancer in men of African ancestry. One such African ancestry specific rare variant, rs72725854 (A>G/T) (~6% allele frequency) has been associated with a ~2-fold increase in prostate cancer risk. However, the...

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Detalles Bibliográficos
Autores principales: Walavalkar, Kaivalya, Saravanan, Bharath, Singh, Anurag Kumar, Jayani, Ranveer Singh, Nair, Ashwin, Farooq, Umer, Islam, Zubairul, Soota, Deepanshu, Mann, Rajat, Shivaprasad, Padubidri V., Freedman, Matthew L., Sabarinathan, Radhakrishnan, Haiman, Christopher A., Notani, Dimple
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368061/
https://www.ncbi.nlm.nih.gov/pubmed/32680982
http://dx.doi.org/10.1038/s41467-020-17325-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368061/
https://www.ncbi.nlm.nih.gov/pubmed/32680982
http://dx.doi.org/10.1038/s41467-020-17325-y

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