The Role of Dihydropyrimidine Dehydrogenase and Thymidylate Synthase Polymorphisms in Fluoropyrimidine-Based Cancer Chemotherapy in an Iranian Population

BACKGROUND: The fluoropyrimidine drug 5-Fluorouracil (5-FU) and the prodrug capecitabine have been extensively used for treatment of many types of cancer including colorectal, gastric, head and neck. Approximately, 10 to 25% of patients suffer from severe fluoropyrimidine-induced toxicity. This may...

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Detalles Bibliográficos
Autores principales: Abbasian, Mohammad Hadi, Ansarinejad, Nafiseh, Abbasi, Bahareh, Iravani, Masoud, Ramim, Tayeb, Hamedi, Fahime, Ardekani, Ali M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368113/
https://www.ncbi.nlm.nih.gov/pubmed/32695278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368113/
https://www.ncbi.nlm.nih.gov/pubmed/32695278

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