Folate stress induces SLX1- and RAD51-dependent mitotic DNA synthesis at the fragile X locus in human cells

Folate deprivation drives the instability of a group of rare fragile sites (RFSs) characterized by CGG trinucleotide repeat (TNR) sequences. Pathological expansion of the TNR within the FRAXA locus perturbs DNA replication and is the major causative factor for fragile X syndrome, a sex-linked disord...

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Detalles Bibliográficos
Autores principales: Garribba, Lorenza, Bjerregaard, Victoria A., Gonçalves Dinis, Marisa M., Özer, Özgün, Wu, Wei, Sakellariou, Despoina, Pena-Diaz, Javier, Hickson, Ian D., Liu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368274/
https://www.ncbi.nlm.nih.gov/pubmed/32601218
http://dx.doi.org/10.1073/pnas.1921219117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368274/
https://www.ncbi.nlm.nih.gov/pubmed/32601218
http://dx.doi.org/10.1073/pnas.1921219117

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