Canine SOD1 harboring E40K or T18S mutations promotes protein aggregation without reducing the global structural stability

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease associated with aggregation of superoxide dismutase 1 (SOD1) protein. More than 160 mutations in human SOD1 have been identified in familial ALS and extensively characterized in previous studies. Here, we invest...

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Detalles Bibliográficos
Autores principales: Kimura, Shintaro, Kamatari, Yuji O., Kuwahara, Yukina, Hara, Hideaki, Yamato, Osamu, Maeda, Sadatoshi, Kamishina, Hiroaki, Honda, Ryo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368427/
https://www.ncbi.nlm.nih.gov/pubmed/32742795
http://dx.doi.org/10.7717/peerj.9512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368427/
https://www.ncbi.nlm.nih.gov/pubmed/32742795
http://dx.doi.org/10.7717/peerj.9512

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