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Canine SOD1 harboring E40K or T18S mutations promotes protein aggregation without reducing the global structural stability
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease associated with aggregation of superoxide dismutase 1 (SOD1) protein. More than 160 mutations in human SOD1 have been identified in familial ALS and extensively characterized in previous studies. Here, we invest...
Autores principales: | Kimura, Shintaro, Kamatari, Yuji O., Kuwahara, Yukina, Hara, Hideaki, Yamato, Osamu, Maeda, Sadatoshi, Kamishina, Hiroaki, Honda, Ryo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368427/ https://www.ncbi.nlm.nih.gov/pubmed/32742795 http://dx.doi.org/10.7717/peerj.9512 |
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