Cervicovaginal cellular angiofibroma

Cellular angiofibroma is a rare type of benign mesenchymal tumour that arises mostly in middle-aged women. It needs to be distinguished from other neoplasms and has a predilection for the vulvovaginal region. To our knowledge, this is the first case of a cervical cellular angiofibroma. A 34-year-old...

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Autores principales: Van Mulders, Sarah, Faes, Ellen, Broeckx, Glenn, Jacquemyn, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368490/
https://www.ncbi.nlm.nih.gov/pubmed/32675122
http://dx.doi.org/10.1136/bcr-2020-235241
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author Van Mulders, Sarah
Faes, Ellen
Broeckx, Glenn
Jacquemyn, Yves
author_facet Van Mulders, Sarah
Faes, Ellen
Broeckx, Glenn
Jacquemyn, Yves
author_sort Van Mulders, Sarah
collection PubMed
description Cellular angiofibroma is a rare type of benign mesenchymal tumour that arises mostly in middle-aged women. It needs to be distinguished from other neoplasms and has a predilection for the vulvovaginal region. To our knowledge, this is the first case of a cervical cellular angiofibroma. A 34-year-old nulligravid woman was referred with a large mass bulging in the fornix posterior. Ultrasound scanning and MRI showed a large solid mass projecting in the pouch of Douglas. Laparoscopic surgical excision was performed. Histopathological examination showed a well-demarcated, unencapsulated tumour, consisting of short fascicles of spindle cells in-between thick-walled medium-sized vessels. On immunohistochemistry, there was strong reactivity with antibodies against CD34 and oestrogen receptor. Angiofibromas are benign mesenchymal tumours mostly occurring in middle-aged women. They can cause abnormal swelling and uterine bleeding and need to be distinguished from other (malignant) neoplasms.
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spelling pubmed-73684902020-07-22 Cervicovaginal cellular angiofibroma Van Mulders, Sarah Faes, Ellen Broeckx, Glenn Jacquemyn, Yves BMJ Case Rep Unusual Presentation of More Common Disease/Injury Cellular angiofibroma is a rare type of benign mesenchymal tumour that arises mostly in middle-aged women. It needs to be distinguished from other neoplasms and has a predilection for the vulvovaginal region. To our knowledge, this is the first case of a cervical cellular angiofibroma. A 34-year-old nulligravid woman was referred with a large mass bulging in the fornix posterior. Ultrasound scanning and MRI showed a large solid mass projecting in the pouch of Douglas. Laparoscopic surgical excision was performed. Histopathological examination showed a well-demarcated, unencapsulated tumour, consisting of short fascicles of spindle cells in-between thick-walled medium-sized vessels. On immunohistochemistry, there was strong reactivity with antibodies against CD34 and oestrogen receptor. Angiofibromas are benign mesenchymal tumours mostly occurring in middle-aged women. They can cause abnormal swelling and uterine bleeding and need to be distinguished from other (malignant) neoplasms. BMJ Publishing Group 2020-07-16 /pmc/articles/PMC7368490/ /pubmed/32675122 http://dx.doi.org/10.1136/bcr-2020-235241 Text en © BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Unusual Presentation of More Common Disease/Injury
Van Mulders, Sarah
Faes, Ellen
Broeckx, Glenn
Jacquemyn, Yves
Cervicovaginal cellular angiofibroma
title Cervicovaginal cellular angiofibroma
title_full Cervicovaginal cellular angiofibroma
title_fullStr Cervicovaginal cellular angiofibroma
title_full_unstemmed Cervicovaginal cellular angiofibroma
title_short Cervicovaginal cellular angiofibroma
title_sort cervicovaginal cellular angiofibroma
topic Unusual Presentation of More Common Disease/Injury
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368490/
https://www.ncbi.nlm.nih.gov/pubmed/32675122
http://dx.doi.org/10.1136/bcr-2020-235241
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