Cargando…

Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells

Tumor-associated antigen (TAA) T-cell receptor (TCR) gene-engineered T cells exhibit great potential in antitumor immunotherapy. Considering the high costs and low availability of patient-derived peripheral blood T cells, substantial efforts have been made to explore alternatives to natural T cells....

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Fangxiao, Huang, Dehao, Luo, Yuxuan, Zhou, Peiqing, Lv, Cui, Wang, Kaitao, Weng, Qitong, Liu, Xiaofei, Guan, Yuxian, Geng, Yang, Du, Juan, Chen, Jiekai, Wang, Jinyong, Wu, Hongling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368548/ https://www.ncbi.nlm.nih.gov/pubmed/32669292 http://dx.doi.org/10.1136/jitc-2019-000498

Ejemplares similares

NUP98‐HOXA10hd fusion protein sustains multi‐lineage haematopoiesis of lineage‐committed progenitors in transplant setting
por: Dong, Yong, et al.
Publicado: (2020)

Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell‐like cells
por: Huang, Dehao, et al.
Publicado: (2022)

Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors
por: Guo, Rongqun, et al.
Publicado: (2019)

Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs
por: Anikeeva, Nadia, et al.
Publicado: (2021)

Sensitive identification of neoantigens and cognate TCRs in human solid tumors
por: Arnaud, Marion, et al.
Publicado: (2021)

Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition
por: Dong, Yong, et al.
Publicado: (2019)

TCRs alive on the periphery
por: Tuma, Rabiya S.
Publicado: (2005)

TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs
por: Genolet, Raphael, et al.
Publicado: (2023)

Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells
por: Peng, Huan, et al.
Publicado: (2023)

Landscape mapping of shared antigenic epitopes and their cognate TCRs of tumor-infiltrating T lymphocytes in melanoma
por: Murata, Kenji, et al.
Publicado: (2020)

Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
por: Dillard, Pierre, et al.
Publicado: (2021)

A protocol for generating induced T cells by reprogramming B cells in vivo
por: Weng, Qitong, et al.
Publicado: (2018)

Turn to TCRs when CARs fail
por: Stauss, Hans J.
Publicado: (2017)

Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing
por: Lu, Yong-Chen, et al.
Publicado: (2021)

Public T-Cell Receptors (TCRs) Revisited by Analysis of the Magnitude of Identical and Highly-Similar TCRs in Virus-Specific T-Cell Repertoires of Healthy Individuals
por: Huisman, Wesley, et al.
Publicado: (2022)

Structural Basis for Self-Discrimination by Neoantigen-Specific TCRs
por: Finnigan, John P., et al.
Publicado: (2023)

PRAME and CTCFL-reactive TCRs for the treatment of ovarian cancer
por: van Amerongen, Rosa A., et al.
Publicado: (2023)

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cells via regulation of the p53-checkpoint pathway
por: Wang, Tongjie, et al.
Publicado: (2020)

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells
por: Huang, Dehao, et al.
Publicado: (2022)

Author Correction: Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells
por: Huang, Dehao, et al.
Publicado: (2023)

Senescent bone marrow microenvironment promotes Nras-mutant leukemia
por: Zhou, Peiqing, et al.
Publicado: (2020)

Tumor targeting of innate and adaptive immunity by the adoptive cell transfer of engineered T lymphocytes co-expressing iNKT and tumor-specific MHC-I TCRs
por: Tschumi, Benjamin O, et al.
Publicado: (2014)

Melanocyte lineage-specific antigen gp100 is recognized by melanoma- derived tumor-infiltrating lymphocytes
Publicado: (1994)

Adoptive Immunotherapy Based on Chain-Centric TCRs in Treatment of Infectious Diseases
por: Kalinina, Anastasiia A., et al.
Publicado: (2020)

Tumor-killing DCs
por: Bashyam, Hema
Publicado: (2007)

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response
por: Schamel, Wolfgang W.A., et al.
Publicado: (2005)

Generation of TCRs of higher affinity by antigen-driven differentiation of progenitor T cells in vitro
por: Schmitt, Thomas M., et al.
Publicado: (2017)

The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution
por: Crooks, James E., et al.
Publicado: (2018)

Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies
por: Meringa, A. D., et al.
Publicado: (2023)

Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer
por: Zhang, Bei, et al.
Publicado: (2023)

Retraining macrophages to kill tumors
por: Bashyam, Hema
Publicado: (2008)

Functionally specialized human CD4(+) T-cell subsets express physicochemically distinct TCRs
por: Kasatskaya, Sofya A, et al.
Publicado: (2020)

Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma
por: Bräunlein, Eva, et al.
Publicado: (2021)

Mass spectrometric identification of immunogenic SARS-CoV-2 epitopes and cognate TCRs
por: Pan, Ke, et al.
Publicado: (2021)

Human tumor antigens recognized by T lymphocytes
Publicado: (1996)

Killing cancer cells by targeted drug-carrying phage nanomedicines
por: Bar, Hagit, et al.
Publicado: (2008)

A tumor that is not a tumor but it sure can kill!
por: Grewal, Harpreet Singh, et al.
Publicado: (2012)

A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell
por: Wiesenthal, Volker, et al.
Publicado: (2006)

Conventional and Regulatory CD4(+) T Cells That Share Identical TCRs Are Derived from Common Clones
por: Wolf, Kyle J., et al.
Publicado: (2016)

Recognition of synthetic polyanionic ligands underlies “spontaneous” reactivity of Vγ1 γδTCRs
por: Dunst, Josefine, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gcju6cgcln2sjg3mf6r17pqkjb