The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum–microglia crosstalk preventing disease progression in a mouse model of Huntington’s disease

The longevity-associated variant (LAV) of the bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been found significantly enriched in long-living individuals. Neuroinflammation is a key player in Huntington’s disease (HD), a neurodegenerative disorder caused by neura...

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Detalles Bibliográficos
Autores principales: Di Pardo, Alba, Ciaglia, Elena, Cattaneo, Monica, Maciag, Anna, Montella, Francesco, Lopardo, Valentina, Ferrario, Anna, Villa, Francesco, Madonna, Michele, Amico, Enrico, Carrizzo, Albino, Damato, Antonio, Pepe, Giuseppe, Marracino, Federico, Auricchio, Alberto, Vecchione, Carmine, Maglione, Vittorio, Puca, Annibale A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368858/
https://www.ncbi.nlm.nih.gov/pubmed/32683420
http://dx.doi.org/10.1038/s41419-020-02754-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368858/
https://www.ncbi.nlm.nih.gov/pubmed/32683420
http://dx.doi.org/10.1038/s41419-020-02754-w

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